In silico analysis of SARS-CoV-2 spike protein N501Y and N501T mutation effects on human ACE2 bindingSARS-CoV-2 스파이크 단백질 N501Y 및 N501T 돌연변이가 인간 ACE2 결합에 미치는 영향에 대한 실리코 분석Article Published on 2022-11-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis analyzed anti-SARS-CoV-2 antibodies Anti-viral drugs antisense attachment binding binding energy binding free energy classic Dynamics Effect Effect of mutations on binding energy effective free energy hACE2 hACE2 receptor hACE2-SARS-CoV-2 spike protein binding. handling highlight Host human ACE2 maintain molecular molecular dynamics molecular dynamics simulations Mutation N501Y N501Y and N501T mutations nine outcome predicted Protein binding raised Replication SARS CoV SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 spike protein Spike protein survival Transmissibility treatment strategy Vaccines virus [DOI] 10.1016/j.jmgm.2022.108260 PMC 바로가기 [Article Type] Article
The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus attachment inhibitor녹차 카테킨 EGCG는 범 코로나바이러스 부착 억제제에 대한 개념 증명을 제공합니다Article Published on 2022-07-282022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Antiviral antiviral activity attachment block catechin caused Cell conserved coronavirus Coronavirus-2 Coronaviruses CoV CoV infection COVID-19 pandemic CoVs EGCG Endemic epigallocatechin epigallocatechin gallate epithelial cells gallate glycans green tea HCoV-OC43 Health heparan sulfate heparin highlight highly pathogenic CoVs Infection inhibitor inhibitors Lentiviral particle lentiviral particles Lung epithelial cells mechanism murine Prevent PROTECT Proteoglycan provide pseudotyped rapid response reduce remained required SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown Spike protein Spike proteins sulfate target cell Treatment Vaccine development virion binding virus [DOI] 10.1038/s41598-022-17088-0 PMC 바로가기 [Article Type] Article
The Cellular Characterization of SARS-CoV-2 Spike Protein in Virus-Infected Cells Using the Receptor Binding Domain Binding Specific Human Monoclonal Antibodies수용체 결합 도메인 결합 특이적 인간 단일클론 항체를 사용하여 바이러스에 감염된 세포에서 SARS-CoV-2 스파이크 단백질의 세포 특성화Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] adopted antibody appearance appears attachment B cell B cells biological properties biological property can be used Cell cell-to-cell transmission characterization conformation conformational change convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient convalescent patient serum Convalescent patients cytoplasmic demonstrated early stage early stages electron microscopy epitope Epitopes Evidence exhibited FIVE focus furin future therapeutic Golgi complex host cell Human human monoclonal antibodies Human monoclonal antibody immunofluorescence microscopy immunological indicated infected cells infected with SARS-CoV-2 Infection Interaction isolate isolates Microscopy mitigate MONITOR monoclonal new virus occur offer Protein provided RBD reagent Receptor binding domain receptor binding domain (RBD). recognize required S protein S protein cleavage S protein RBD SARS- CoV-2 SARS-CoV-2 SARS-CoV-2 clinical isolates SARS-CoV-2 spike SARS-CoV-2-infected cell SARS-CoV-2-infected cells Singapore Specific spike staining the RBD the S protein therapeutic These data Transmission Vaccine variant virus infection virus particles virus-infected cell virus-infected cells was used were used while [DOI] 10.1128/jvi.00455-22 PMC 바로가기 [Article Type] Article
Biodistribution and Cellular Internalization of Inactivated SARS-CoV-2 in Wild-Type Mice야생형 마우스에서 비활성화된 SARS-CoV-2의 생체분포 및 세포 내재화Article Published on 2022-07-092022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 ACE2 receptors administration analyzed angiotensin attachment Brain can not caveolin cell entry receptor cell line cellular cellular uptake clathrin Consensus conserved expression heart help heparan sulfate heparan sulfate proteoglycans heparin human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 in vitro in vivo inactivated infected with SARS-CoV-2 Inflammation internalization intravenous Intravenous administration mammalian mice molecular interaction motif mouse Muridae murine organ Proteoglycan raised reported SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 receptors Spike protein sulfate syndecan syndecan-4 syndecans syndecans. tissue TNF-α transmembrane various tissues wild-type [DOI] 10.3390/ijms23147609 PMC 바로가기 [Article Type] Article
A multilevel approach for screening natural compounds as an antiviral agent for COVID-19COVID-19에 대한 항바이러스제로서 천연 화합물을 스크리닝하기 위한 다단계 접근법Article Published on 2022-06-012022-09-11 Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] analyses Analysis analyzed Antiviral approach attachment AutoDock vina Cluster analyses Compound computer-aided drug design COVID-19 database DFT disrupt docked docking domain drug drug design drug treatments drug-likeness effort exploratory Frame high-affinity binding host cell host cells identify inhibitor inhibitors Interaction ligands machine learning approach machine learning approaches Prevent Principal component principal component analysis principal component analysis. protein-ligand interaction protocol RBD RBD domain RBD region SARS-CoV-2 spike receptor-binding domain Spread the RBD therapeutic agent was performed [DOI] 10.1016/j.compbiolchem.2022.107694 PMC 바로가기 [Article Type] Article
The Role of Spike Protein Mutations in the Infectious Power of SARS-COV-2 Variants: A Molecular Interaction PerspectiveSARS-COV-2 변이체의 전염력에서 스파이크 단백질 돌연변이의 역할: 분자 상호작용 관점Article Published on 2022-04-052022-09-11 Journal: Chembiochem [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 receptor among others Analysis attachment B.1.1.28.1 B.1.351 bond Brazil correlated domain E484K mutation Effects Europe host cells hydrogen Hydrogen bond IMPROVE initial K417N molecular molecule molecules N501Y natural P.1 P.2 pair power quantum Quantum mechanics quantum theory RBD Receptor binding domain recognize reported residue residues role S477N Salt Bridge salt bridges SARS-CoV-2 virus significantly South Africa Specific spike Spike protein the spike protein theory United Kingdom variant virus wild type [DOI] 10.1002/cbic.202100393 PMC 바로가기 [Article Type] Article
SARS-CoV-2: Receptor and Co-receptor Tropism ProbabilitySARS-CoV-2: 수용체 및 공동 수용체 방향성 확률Review Published on 2022-03-162022-09-11 Journal: Current microbiology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 distribution acute respiratory syndrome addition Amino acid amino acids angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 attachment binding broad spectrum caused cells cellular cellular component China Co-receptor coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 disease domain entry of SARS-CoV-2 extreme facilitate Factor first stage help heterogeneous Host host cell hosts humans infect mechanisms membrane molecular organs pandemic Pathogenesis pathogenesis of COVID-19 pathogenic virus Perspective Prevent protease Proteases public health RBD receptor Receptor-binding domain receptor-binding domains receptors required SARS-CoV-2 SARS-CoV-2 spike protein Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus-2 severity Spike protein Spike proteins susceptibilities the SARS-CoV-2 the spike protein tissues Treatment strategies tropism understanding virus entry [DOI] 10.1007/s00284-022-02807-7 PMC 바로가기 [Article Type] Review
Discovery of a Natural Product with Potent Efficacy Against SARS-CoV-2 by Drug Screening약물 스크리닝을 통해 SARS-CoV-2에 강력한 효능을 지닌 천연물 발견Article Published on 2022-03-012022-09-11 Journal: Interdisciplinary sciences, computational life sci [Category] SARS, 신약개발, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against alveolar epithelial cells Analysis angiotensin angiotensin-converting enzyme-2 Antiviral antiviral peptides antiviral properties attachment AVP binding binding affinity binding free energies binding free energy caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cyanovirin-N demonstrated domain drug Drug screening enzyme epithelial cells half-maximal inhibitory concentration host cell host cells human Angiotensin-converting enzyme Infection inhibit inhibited Interaction Molecular simulation natural Novel coronavirus novel coronavirus disease peptide peptides potent Prevent product provided RBD RBD binding RBD complex Receptor-binding domain recruitment residue SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2. Screening severe acute respiratory syndrome Coronavirus spike glycoprotein Spread Structural analysis suppressed Therapeutic approach [DOI] 10.1007/s12539-021-00477-w PMC 바로가기 [Article Type] Article
Effectiveness of an online versus face-to-face psychodynamic counselling intervention for university students before and during the COVID-19 periodResearch Published on 2022-02-222022-10-28 Journal: BMC Psychology [Category] Coronavirus, COVID19(2023년), Fulltext, MERS, SARS, [키워드] Adverse Anxiety attachment Attachment styles checklist childhood COVID-19 COVID-19 pandemic Depression effective Effectiveness evaluate experience face-to-face intervention face-to-face interventions in both group index Intervention life Life satisfaction moderate no difference no significant difference Online university counselling intervention pandemic problem Psychodynamic university counselling Psychological Psychological distress Psychopathological problems reducing Result Satisfaction scale seeking sensitivity student were assessed [DOI] 10.1186/s40359-022-00742-7 PMC 바로가기 [Article Type] Research
Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lungDiltiazem은 SARS-CoV-2 세포 부착 및 내재화를 억제하고 마우스 폐의 바이러스 감염을 감소시킵니다Research Article Published on 2022-02-172022-09-10 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] ACE2 Affect affecting anti-SARS-CoV-2 antiviral drug antiviral drugs appear approved attachment Author binding blocker Breakthrough infection breakthrough infections calcium calcium channel Cell Clinical practice coronavirus COVID-19 COVID-19 treatment decrease Diltiazem drug drugs Effectiveness Emergency use FDA-approved drug highlight hospitalized COVID-19 patients indications inhibit interact internalization L-type lung occurred raise recipient recipients Remdesivir Research research and development respiratory Respiratory Coronavirus Safe SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike protein SARS-CoV-2 vaccine SARS-CoV-2 vaccines severe acute respiratory coronavirus Spike protein subunit Support the vaccine the vaccines treat Treatment US FDA variant variants variants of SARS-CoV-2 Viral viral entry viral infection [DOI] 10.1371/journal.ppat.1010343 PMC 바로가기 [Article Type] Research Article